A Rabbit Model of Hormone-induced Early Avascular Necrosis of the Femoral Head

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A rabbit model of hormone-induced early avascular necrosis of the femoral head.

OBJECTIVE To establish an experimental model of early stage avascular necrosis of the femoral head (ANFH) caused by corticosteroid in adult rabbits and to observe the pathological changes with various imaging techniques. METHODS ANFH was induced by a combination of hypersensitivity vasculitis caused by injection of horse serum and subsequent administration of a high dose of corticosteroid. Th...

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Avascular Necrosis of the Femoral Head: Are Any Genes Involved?

Avascular necrosis of the femoral head (ANFH) is a pathologic process that results from interruption of blood supply to the femur bone resulting in the death of bone cells and collapse of the femoral head. Nontraumatic ANFH continuesto be a significant challenge to orthopedic surgeons. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade tha...

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Avascular necrosis of the femoral head.

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Cortisone-induced avascular necrosis of the femoral head.

Of ninety-five patients with corticosteroid-induced avascular necrosis of bone, ninety-one had involvement of the femoral head. The risk of developing this lesion appeared to be correlated with the total steroid dose. Forty-nine patients demonstrated a subchondral osteolytic defect which healed without proceeding to collapse. Four femoral heads in four patients developed sequestration, resembli...

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Avascular Necrosis of the Femoral Head

Since the recent publication of studies of the vascular pattern of the proximal femoral epiphysis in man by Tucker (1949), Trueta and Harrison (1953), Judet, Judet, Lagrange and Dunoyer (1955), and Trueta (1957) there has been a renewed interest in the mechanism of capital necrosis after fractures of the femoral neck. The literature on the subject is so extensive that no effort will be made her...

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ژورنال

عنوان ژورنال: Biomedical and Environmental Sciences

سال: 2008

ISSN: 0895-3988

DOI: 10.1016/s0895-3988(08)60060-4